The interproximal cleaning appliance includes a housing (12) and a spray applicator (16) extending therefrom for directing a spray of fluid droplets to the interproximal area. Within the housing is a spray-generating assembly (14) which includes a chamber, a movable piston (26) mounted therein, one-way inlets (42, 40) for gas and fluid and an outlet (44). A system (54) for moving the piston, such as a motor, operatively compresses a spring (32) which creates a partial vacuum in the chamber, allowing gas to flow into the chamber through the gas inlet. Release of the spring produces a stream of fluid droplets which flows out of the chamber through the applicator to the interproximal area.