Inc.;VentiRx Pharmaceuticals;Array Biopharma, Inc.;VentiRx Pharmaceuticals, Inc.
发明人:
HOWBERT, James Jeffry,HERSHBERG, Robert,BURGESS, Laurence E.,YANG, Hong Woon
申请号：
ES12734770
公开号：
ES2620606T3
申请日:
2012.01.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having the formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which it is a double bond or a single bond； R2 and R3 are independently selected from H and unsubstituted or substituted C1-C6 alkyl, wherein C1-C6 alkyl is optionally substituted with halogen, C1-C6 alkyl, C1-C6 alkoxy, keto, amino, alkylamino, dialkylamino, trifluoromethyl, aryl, heteroaryl or hydroxyl, or R2 and R3, together with the carbon atom to which they are attached, form a saturated carbocycle having 3 to 7 members, or R3 and one of Ra or Rb, together with atoms a those that are attached, form a 5-7 membered heterocyclic ring； R7 is selected from the group consisting of: ** Formula ** n is 0, 1, 2 or 3； each R8 is independently selected from unsubstituted or substituted C1-C6 alkoxy, halogen, trihalomethyl, unsubstituted or substituted C1-C6 alkoxycarbonyl, nitro, unsubstituted or substituted carbonylamino, unsubstituted or substituted sulfonamide, unsubstituted or substituted heterocycle which it comprises 1 or 2 rings of 5 or 6 members and 1-4 ** Formula ** heteroatoms selected from N, O and S, and wherein each of said C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl , carbonylamino, and sulfonamide is optionally substituted, independently, with halogen, C1-C6 alkyl, C1-C6 alkoxy, keto, amino, C1-C6 alkylamino, di (C1-C6 alkyl) amino, trifluoromethyl, aryl, heteroaryl or hydroxyl； and said heterocycle is optionally substituted with one or more groups independently selected from C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, cyano, nitro, amino, mono (C1-C6) amino, dialkyl (C1-C6) amino, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, (C1-C6) aminoalkyl (C1-C6) aminoalkyl (C1-C6) or dialkyl (C1-C6) aminoalkyl (C1-) C6)； R9 is unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxy, or -NRhRj, wherein each of said C1-C6 alkyl and C1-C6 alkoxy is optionally independently substituted with halogen, alkyl C1-C6, C1-C6 alkox
