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FORMULATIONS STABLES
专利权人:
AMGEN INC.
发明人:
MCAULEY, ARNOLD,REHDER, DOUGLAS,MATSUMURA, MASAZUMI
申请号:
CA2665567
公开号:
CA2665567C
申请日:
2007.10.05
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The invention provides a formulation including an acetic acid buffer, a glutamic acid buffer or a succinic acid buffer with a pH from about 4.5-7.0, at least one excipient comprising a sugar or a polyol and an effective amount of a therapeutic antibody. The buffer can include a salt of acetate, glutamate or succinate and the sugar or polyol can include glycerol, sucrose, trehalose or sorbitol. The therapeutic antibody can include a human antibody, a humanized antibody, a chimeric antibody, or a functional fragment thereof.
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