CTLA-4 variants

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专利权人:

MedImmune Limited; LLC;MedImmune, LLC;MedImmune

发明人:

Minter, Ralph,Douthwaite, Julie,Moisan, Jacques,Bowen, Michael,Rust, Steve,Privezentzev, Cyril

申请号：

AU2013260172

公开号：

AU2013260172B2

申请日:

2013.03.11

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for subcutaneous or intravenous administration, e.g. at monthly or less frequent dosage intervals. Use of CTLA-4 variants for treating rheumatoid arthritis and other inflammatory disorders. Fusion of CTLA-4 with IgG Fc having improved stability and longer in vivo half-life.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/