Albert Charles Gyorkos;Christopher Stephen Siedem;Scott Alan Pratt;Michiyo Mochizuki;Christopher Peter Corrette;Suk Young Cho;Kazuyoshi Aso
发明人:
Kazuyoshi Aso,Michiyo Mochizuki,Albert Charles Gyorkos,Christopher Peter Corrette,Suk Young Cho,Scott Alan Pratt,Christopher Stephen Siedem
申请号：
US11919435
公开号：
US08163935B2
申请日:
2006.04.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
There is provided a CRF receptor antagonist comprising a compound of the formula (I):wherein R1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic group, an optionally substituted N-linked heteroaryl group, a cyano or an acyl； R2 is an optionally substituted cyclic hydrocarbyl or an optionally substituted heterocyclic group； X is oxygen, sulfur or —NR3— (wherein R3 is a hydrogen, an optionally substituted hydrocarbyl or an acyl)； Y1, Y2 and Y3 are each an optionally substituted carbon or a nitrogen, provided that one or less of Y1, Y2 and Y3 is nitrogen； and Z is a bond, —CO—, oxygen, sulfur, —SO—, —SO2—, —NR4—, —NR4-alk-, —CONR4— or —NR4CO— (wherein alk is an optionally substituted C1-4 alkylene and R4 is a hydrogen, an optionally substituted hydrocarbyl or an acyl)； or a salt thereof or a prodrug thereof.
