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Macrocyclic compounds as IRAK 1/4 inhibitors and uses thereof
专利权人:
Merck Patent GmbH
发明人:
Chen, Xiaoling,Yu, Henry,Lan, Ruoxi,Jorand-Lebrun, Catherine,Johnson, Theresa L.,Goutopoulos, Andreas
申请号:
AU2016215185
公开号:
AU2016215185A1
申请日:
2016.02.05
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors. Wherein: Ring A is a 5-membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5- membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; Ring B is a 6-membered aryl, or a 6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; Ring C is a 5-membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5- membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted.
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