A use of an active ingredient in the manufacture of a preparation is provided, wherein the active ingredient is selected from a group consisting of ergosterol, a pharmaceutically acceptable ester of ergosterol and combinations thereof, and the preparation is a medicament, a food or a food additive for alleviating, inhibiting or treating nephropathy.一種使用一活性成分於製造一製劑的用途,其中該活性成分係選自以下群組:麥角固醇(Ergosterol)、其醫藥上可接受之酯、及前述之組合,且該製劑係一藥劑、一食品、或一食品添加劑,用於減緩、抑制及/或治療腎臟病變(Nephropathy)。