This disclosure relates to can be used what adjust apolipoprotein A-1 (ApoA-I) expression compound and they treating and preventing cardiovascular disease and associatcd disease state, including disorder related with cholesterol or lipid, the purposes in such as atherosclerosis.本公開內容涉及可用於調節載脂蛋白A-I(ApoA-I)的表達的化合物以及它們在治療和預防心血管疾病和相關疾病狀態、包括與膽固醇或脂質有關的紊亂、例如動脉粥樣硬化中的用途。