The present disclosure provides a use based on Zn7MT3 or a derivative thereof. Zn7MT3 or a derivative thereof is used for prevention or treatment of Alzheimer's disease or other neurodegenerative diseases, or for development, screening or preparation of a medicament suitable for Alzheimer's disease or other neurodegenerative diseases. Further provided are a method for preparing Zn7MT3 and a method for preparing gH625-Zn7MT3. Zn7MT3 and the derivatives thereof of the present disclosure can be used for improving cognitive dysfunction of an AD brain, regulating the cellular morphology of hippocampus in the AD brain, inhibiting the deposition of the amyloid protein in the AD brain and inhibiting the apoptosis of nerve cells in the brain, and can effectively prevent the progression of senile dementia； and the method for preparing Zn7MT3 is simple and efficient, and gH625-Zn7MT3 can easily cross the blood-brain barrier.
