607496 Disclosed is the use of a composition comprising: a potassium channel opener/agonist and/or an adenosine receptor agonist, together with a local anaesthetic for the preparation of a medicament for reducing damage to a tissue, organ or cell resulting from periods of reduced activity wherein the medicament is administered as an additive during the recovery phase from surgery, while perfusing the heart during a quiescent state following cardioplegic arrest or prior to cardioplegia.The composition may comprise adenosine and lignocaine
