PROBLEM TO BE SOLVED: To provide medicine-containing particles reduced in unpleasant taste in oral cavity of a medicine having unpleasant taste and a solid pharmaceutical preparation containing the particles, substantially not feeling unpleasant taste of the medicine and having good elution property in the digestive tract.SOLUTION: There is provided a medicine-containing particles obtained by coating a medicine-containing composition containing a medicine having unpleasant taste with a coating composition containing (1) an enteric polymer, (2) a disintegrator and (3) an aggregation-preventing agent and granulating the coated composition, and a solid pharmaceutical preparation, e.g. tablets quickly disintegrating in oral cavity, containing the particles.COPYRIGHT: (C)2008,JPO&INPIT【課題】 不快な味を有する薬物の口腔内での不快な味を低減させた薬物含有粒子、および該粒子を含む固形製剤であって、当該薬物の不快な味を実質的に感じず、且つ消化管内において溶出性のよい製剤の提供。【解決手段】 本発明は、不快な味を有する薬物を含む薬物含有組成物を、下記成分(1)腸溶性高分子、(2)崩壊剤、および(3)凝集防止剤を含む被覆組成物で被覆造粒した薬物含有粒子、並びに該粒子を含む口腔内速崩壊錠などの固形製剤を提供する。【選択図】 なし
