HIPSKIND, PHILIP ARTHUR,PATEL, BHARVIN KUMAR,WILSON (NEE TAKAKUMA), TAKAKO
申请号：
PE0021192011
公开号：
PE10502012A1
申请日:
2010.06.15
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula (i) wherein: R1 is H or Methyl R2 is H or Methyl R3, R4, R5, R6 and R7 are independently h, halogeno, cyano, trifluoromethyl, metilsulfonio, among others. Preferred compounds are: 4 - fluoro - N - methyl - N - (1 - (4 - (1 - methyl - 5 - 1H pyrazole - il) ftalazin - il - 1, il) piperidin-4-yl) - 2 - (trifluoromethyl) benzamide among others. In addition to such a Pharmaceutical composition.This Compound is a trajectory of Hedgehog antagonist useful in the treatment of cancerSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES H O METILO R2 ES H O METILO R3, R4, R5, R6 O R7 SON INDEPENDIENTEMENTE H, HALOGENO, CIANO, TRIFLUOROMETILO, METILSULFONIO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-FLUORO-N-METIL-N-(1-(4-(1-METIL-1H-PIRAZOL-5-IL)FTALAZIN-1-IL)PIPERIDIN-4-IL)-2-(TRIFLUOROMETIL)BENZAMIDA ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN ANTAGONISTA DE LA TRAYECTORIA DE HEDGEHOG UTIL EN EL TRATAMIENTO DEL CANCER
