Refers to compounds derived from 1 - [2 - (aminomethyl) benzyl] - 2 - - - - One, two, three, Six tioxo Tetrahydro 4h pyrrolo [3,2-d] 4 - One pyrimidine of formula (i) wherein R1 is H, F, cl or Cf3 R2 is H or CH3, C2H5 R3 is H, CH3, C2H5, Isopropyl, among others.Preferred compounds are: 1 - {2 - [(1R) - 1 - (4-chlorobenzyl) Aminopropyl] 2 - - - - - One, two, three, Six tioxo Tetrahydro 4h pyrrolo [3,2-d] pyrimidine - 4 - One 1 - {4-chloro-2 - [1 - (methylamino) ethyl] benzyl} - 2 - - - - One, two, three, Six tioxo Tetrahydro 4h pyrrolo [3,2-d] pyrimidine - 4 - One among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Myeloperoxidase (MPO) being useful in the treatment of heart failureSE REFIERE A COMPUESTOS DERIVADOS DE 1-[2-(AMINOMETIL)BENCIL]-2-TIOXO-1,2,3,5-TETRAHIDRO-4H-PIRROLO[3,2-d]PIRIMIDIN-4-ONA DE FORMULA (I) DONDE R1 ES H, F, Cl O CF3 R2 ES H, CH3 O C2H5 R3 ES H, CH3, C2H5, ISOPROPILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-{2-[(1R)-1-AMINOPROPIL]-4-CLOROBENCIL}-2-TIOXO-1,2,3,5-TETRAHIDRO-4H-PIRROLO[3,2-d]PIRIMIDIN-4-ONA 1-{4-CLORO-2-[1-(METILAMINO)ETIL]BENCIL}-2-TIOXO-1,2,3,5-TETRAHIDRO-4H-PIRROLO[3,2-d]PIRIMIDIN-4-ONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA MIELOPEROXIDASA (MPO) SIENDO UTILES EN EL TRATAMIENTO DE LA INSUFICIENCIA CARDIACA
