Refers to compounds (AZA) piridopirazolpirimidinonas and indazolpirimidinonas replaced formula (i-a), processes for their preparation for the treatment of acute Bleeding, such as menorrhagia, Myocardial, hepatic diseases, etc.Where R1 is H or alquiloc1 - C4 R2 is n or C - X1 x2 is n or C - R3 X3 is n or C - R4, R5 X4 is n or C, with the proviso that 0, 1 or 2 x1 to X4 are nitrogen R2, R3, R4 and R5 are H, halogen, etc. with the exception that Zero, One. Two or three of R2 R5 H are different.Preferred compounds are: hydrochloride 4 - (piperidin-4-yl pirimido il) [1,2-b] - 2 - (1h indazol Ona hydrochloride hydrochloride 4 - (piperidin-4-yl il) - 9 - (trifluoromethyl) pirimido [1,2-b] indazol - 2 (1H) - One, among othersSe refiere a compuestos (aza)piridopirazolpirimidinonas e indazolpirimidinonas sustituidas de formula (I-A), procesos para su preparacion para el tratamiento de sangrado agudo, como menorragia, infarto, enfermedades hepaticas, etc. Donde: R1 es H o alquiloC1-C4 X1 es N o C-R2 X2 es N o C-R3 X3 es N o C-R4 X4 es N o C-R5 con la salvedad que 0, 1 o 2 de X1 a X4 son nitrogeno R2, R3, R4 y R5 son H, halogeno, etc. con la salvedad que cero, uno. Dos o tres de R2 a R5 son diferentes de H. Son compuestos preferidos: clorhidrato de 4-(Piperidin-4-il)pirimido[1,2-b]indazol-2(1H-ona clorhidrato clorhidrato de 4-(piperidin-4-il)-9-(trifluorometil)pirimido[1,2-b]indazol-2(1H)-ona, entre otros
