Pharmaceutical compositions containing them and Methods of their use as agents for the treatment and / or the Prevention of Lung diseases, Gastrointestinal and Genitourinary inflammatory diseases of the skin and eyes and other autoimmune Disorders and allergic aloinjert Rejection Os and oncological diseases.Claim 1, characterized in that: compounds have the formula (1) where is heteroanillo Aromatic phenyl or a five or six members, where one, two or three elements are replaced by a selected element, independent of each other, the group consisting of (n, O u207b) - n u207a, o and S； r u00b9 u1d43 is a remainder formula (2) or (3)； r u00b9 u1d43.1 is c u2081 u208b u2084 c u2083 u208b u2086 alkyl, cycloalkyl, haloalquilo c u2081 u208b u2084, h u2082n c u2081 u208b u2084 alkyl -, - NH -, cicloalquil c u2083 u208b u2086 - NH -, (c u2081 u208b u2084 u2082n alkyl) -, (cicloalquil c u2083 u208b u2086) n - (alkyl c u2081 u208b u2084), azetidinilo, pirrolidinilo, piperidinilo, morfolinilo, piperazinilo, piperazinil alkyl C u2081 u208b u2084 c u2081 u208b u2084, alkyl - or - NH -, (c u2081 u208b u2084 - or alkyl (alkyl) - n c u2081 u208b u2084)； r u00b9 u1d43.And o u2082n is H, CN -, -, - SO u2082 c u2081 u208b u2084 alkyl -, aryl SO u2082 - (heteroanillo Aromatic) - SO u2082 c u2081 u208b u2084 -, alkyl - or - C (o) -, - C (o) c u2081 u208b u2084 alkyl -, - C (o) cicloalquil c u2083 u208b u2086 h u2082n -, - C (o) c u2081 u208b u2084 - NH -, alkyl - (OR) - C, cicloalquil c u2083 u208b u2086 - NH - (OR) C - (alkyl c u2081 u208b u2084) u2082n - (OR) - C (cicloalquil c u2083 u208b u2086) (c u2081 u208b u2084 alkyl) - N - (o) C (o) azetidinil -, C -, - C (o) - pirrolidinil, piperidinil - (OR) - C (o) morfolinil -, C -, - C (o) piperazinil piperazinil - alkyl -, - C (o) - c u2081 u208b u2084,C u2081 u208b u2084 c u2083 u208b u2086 alkyl, cycloalkyl, aryl, heteroaryl； haloalquilo c u2081 u208b u2084, r u00b9 u1d47 c u2081 u208b u2084 is H, alkyl, cycloalkyl c u2083 u208b u2086
