Freyne, Eddy Jean Edgard,Embrechts, Werner Constant Johan,Emelen, Kristof van,Willems, Marc,Buijnsters, Peter Jacobus Johannes Antonius,Perera, Timothy Pietro Suren,Storck, Pierre Henri,Poncelet, Virg
申请号：
NO20063323
公开号：
NO337701B1
申请日:
2006.07.18
申请国别(地区):
NO
年份:
2016
代理人:
摘要：
The present invention concerns the compounds of formula wherein a1-a2=a3-a4 represents a divalent radical selected from N&mdashCH&boxHCH&mdashCH, N&mdashCH&boxHN&mdashCH or CH&mdashCH&boxHN&mdashCH Z represents NH Y represents &mdashC3-9alkyl-, &mdashC1-5alkyl-NR13&mdashC1-5alkyl-, &mdashC1-6alkyl-NH&mdashCO&mdash or &mdashCO&mdashNH&mdashC1-6alkyl- X1 represents &mdashO&mdash or &mdashNR11&mdash X2 represents &mdashC1-2alkyl-, &mdashO&mdashC1-2alkyl, &mdashO&mdash or &mdashO&mdashCH2&mdash R1 represents hydrogen or halo R2 represents hydrogen, cyano, halo, hydroxycarbonyl-, C1-4alkyloxycarbonyl-, Het16-carbonyl- or Ar5 R3 represents hydrogen R4 represents hydroxy, C1-4alkyloxy-, Ar4&mdashC1-4alkyloxy or R4 represents C1-4alkyloxy substituted with one or where possible two or more substituents selected from C1-4alkyloxy- or Het2- R11 represents hydrogen R12 represents hydrogen, C1-4alkyl- or C1-4alkyl-oxy-carbonyl- R13 represents Het14-C1-4alkyl, in particular morpholinyl-C1-4alkyl Het2 represents a heterocycle selected from morpholinyl or piperidinyl optionally substituted with C1-4alkyl-, preferably methyl Het14 represents morpholinyl Het16 represents a heterocycle selected from morpholinyl or pyrrolidinyl Ar4 represents phenyl Ar5 represents phenyl optionally substituted with cyano.
