PROBLEM TO BE SOLVED: To provide an antigen-binding molecule having an agonist activity to TNF superfamily or TNF receptor superfamily which activates immune cells and exhibits an excellent antitumor effect while avoiding toxicity, and the antigen-binding molecule as an active ingredient. And a method for treating cancer by the pharmaceutical composition. An antigen binding comprising the following domains: (1) a cancer-specific antigen binding domain, and (2) a tumor necrosis factor (TNF) superfamily binding domain or a tumor necrosis factor (TNF) receptor superfamily binding domain. molecule. [Selection diagram] Fig. 3【課題】毒性を回避しつつ免疫細胞を活性化し優れた抗腫瘍効果を発揮するTNFスーパーファミリー又はTNF受容体スーパーファミリーに対してアゴニスト活性を有する抗原結合分子、および、当該抗原結合分子を有効成分として含む医薬組成物、または当該医薬組成物による癌の治療方法を提供。【解決手段】下記のドメイン：（１）癌特異的抗原結合ドメイン、及び（２）腫瘍壊死因子(TNF)スーパーファミリー結合ドメイン又は腫瘍壊死因子(TNF)受容体スーパーファミリー結合ドメインを含む、抗原結合分子。【選択図】図３
