PROBLEM TO BE SOLVED: To provide an antigen binding molecule capable of promoting the intake of an antigen into the cell, which can bind increased number of antigen per one molecule, of which administration promotes reduction of the antigen in the plasma with longer pharmacokinetics, as well as a pharmaceutical composition containing the antigen binding molecule, and methods for producing the same.SOLUTION: Disclosed is an antigen binding molecule comprising a sugar chain receptor binding domain, of which antigen-binding activity is weak at a pH in early stage endosome as compared with the activity at a pH in the plasma.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】抗原の細胞内への取込が促進されるとともに、１分子の抗体が結合できる抗原の数を増加させることが可能になり、抗体の投与により血漿中の抗原減少を促進するとともに、抗体の薬物動態を長くすることが可能となる、抗原結合分子、抗原結合分子を含む医薬組成物、及びそれらの製造方法の提供。【解決手段】糖鎖受容体結合ドメインを含み、血漿中でのｐＨにおける抗原結合活性と比較して早期エンドソーム内でのｐＨにおける抗原結合活性が弱い抗原結合分子。【選択図】なし
