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COMPLEX OF AMORPHOUS TOMOXIPROLE AND CYCLODEXTRIN WITH FAST DISSOLUTION RATE AND PROCESS FOR THE PREPARATION THEREOF
专利权人:
Alberto Milanese;Marino Nebuloni;Lucia Carrano
发明人:
Alberto Milanese,Marino Nebuloni,Lucia Carrano
申请号:
US14125468
公开号:
US20140128343A1
申请日:
2012.06.14
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.
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中国工程科技知识中心
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