Modified CK and CH1 domains

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专利权人:

I-MAB

发明人:

Wang, Yongqiang,Fang, Lei,Wang, Zhengyi,Guo, Bingshi,Zang, Jingwu

申请号：

AU2019203917

公开号：

AU2019203917A1

申请日:

2019.01.15

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

#$%^&*AU2019203917A120190801.pdf#####ABSTRACT Provided are antibody and antigen-binding fragment with modified CK and CHI domains that still enable pairing of the CK and CHI domains but have reduced pairing compared to wild type CHI and CK domains without the modification. Such modifications can particularly useful for preparing bispecific antibodies which two different pairs of CK and CHI domains. -69-

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/