MODIFIED Cκ AND CH1 DOMAINS

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专利权人:

I-MAB BIOPHARMA US LIMITED

发明人:

WANG, Yongqiang,FANG, Lei,WANG, Zhengyi,GUO, Bingshi,ZANG, Jingwu

申请号：

SG11202005009R

公开号：

SG11202005009RA

申请日:

2019.01.15

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

Provided are antibody and antigen-binding fragment with modified Cκ and CH1 domains that still enable pairing of the Cκ and CH1 domains but have reduced pairing compared to wild type CH1 and Cκ domains without the modification. Such modifications can particularly useful for preparing bispecific antibodies which two different pairs of Cκ and CH1 domains.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/