DOMAINES CK ET CH1 MODIFIES

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专利权人:

I-MAB BIOPHARMA US LIMITED

发明人:

WANG, YONGQIANG,FANG, LEI,WANG, ZHENGYI,GUO, BINGSHI,ZANG, JINGWU

申请号：

CA3084398

公开号：

CA3084398A1

申请日:

2019.01.15

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Provided are antibody and antigen-binding fragment with modified C? and CH1 domains that still enable pairing of the C? and CH1 domains but have reduced pairing compared to wild type CH1 and C? domains without the modification. Such modifications are particularly useful for preparing bispecific antibodies with two different pairs of C? and CH1 domains.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/