FORMULATION DE MEDICAMENTS A LIBERATION RANLENTIE AVEC UNE COUCHE EXTERIEURE COMPRENANT UN POLYMERE DEGRADABLE PAR DES ENZYMES, SA COMPOSITION ET SON PROCESSUS DE PRODUCTION
A method of producing a coatable core for a delayed release drug formulation for oral administration to deliver a drug to the colon. The method comprises forming a core comprising a drug. An outer layer coating preparation is formed by combining a first aqueous preparation of an enzymatically degradable polymer which is degradable by colonic bacterial enzymes； a second aqueous preparation of a film-forming enteric polymer having a pH threshold of about pH 6 or above； and an organic anti-tack agent. The core is then coated with the outer layer coating preparation to form an outer layer coated core.
