The present invention provides a vaccine for enteroviruses. In view of the structure of enteroviruses, particularly VP0's cleaving VP2 and VP4, it was discovered that said cleaving affects immunogenicity. In other words, it is believed that designing a vaccine including a large amount of VP2 and VP4 as polypeptides which exhibit immunogenicity leads to providing a vaccine which exhibits high immunogenicity. Polypeptides including VP1, VP2, VP3, and VP4 derived from an enterovirus are produced, and these polypeptides are confirmed to have a high effect as an immunogen against enteroviruses.本發明之課題在於提供一種針對腸病毒之疫苗。解決手段如下：著眼於腸病毒結構、特別是VP0會分裂成VP2與VP4，即發現該分裂會影響免疫原性。亦即，可認為設計出含有許多VP2與VP4作為顯示免疫原性之多肽的疫苗，會關係到提供一種顯示高免疫原性之疫苗。已確認製造含有源自腸病毒之VP1、VP2、VP3及VP4之多肽，該多肽作為針對腸病毒之免疫原具有高效果。
