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CHIMERIC ANTIGEN RECEPTOR SPECIFIC FOR FOLATE RECEPTOR BETA
专利权人:
The Trustees of The University of Pennsylvania
发明人:
Daniel J. Powell, JR.
申请号:
US14211784
公开号:
US20140286973A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML). The invention also relates to at least one chimeric antigen receptor (CAR) specific to folate receptor beta (FRβ), vectors comprising the same, and recombinant T cells comprising the FRβ CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a FRβ binding domain in combination with a RXR agonist, such as all-trans retinoic acid.
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中国工程科技知识中心
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