Marcela Maus;Hideho Okada;Carl H. June;John Scholler;Laura Alexandra Johnson;Jennifer Brogdon;Andreas Loew
发明人:
Jennifer Brogdon,Laura Alexandra Johnson,Carl H. June,Andreas Loew,Marcela Maus,John Scholler,Hideho Okada
申请号：
US14184924
公开号：
US09394368B2
申请日:
2014.02.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
