The Trustees of The University of Pennsylvania;Novartis AG;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
Jennifer Brogdon,Laura Alexandra Johnson,Carl H. June,Andreas Loew,Marcela Maus,John Scholler,Hideho Okada
申请号：
US16382402
公开号：
US20190330356A1
申请日:
2019.04.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
