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PYRROLODINYL ALKYLAMIDE DERIVATIVES, THEIR OBTAINING AND THERAPEUTIC APPLICATION AS LIGANDS OF CCR3 RECEPTOR
专利权人:
SANOFI-AVENTIS
发明人:
PAPPNE BEKhR Agnes (HU),ПАППНЕ БЕХР Агнес (HU),BATORI Shandor (HU),БАТОРИ Шандор (HU),BARTANE BODOR Veronika (HU),БАРТАНЕ БОДОР Вероника (HU),SLAVIK Zol'tan (HU),СЛАВИК Зольтан (HU),BATA Imre (HU),БАТ,PAPPNE BEKHR AGNES,ПАППНЕ БЕХР Агнес,BATORI SHANDOR,БАТОРИ Шандор,BARTANE BODOR VERONIKA,БАРТАНЕ БОДОР Вероника,SLAVIK ZOLTAN,СЛАВИК Зольтан,BATA IMRE,БАТА Имре,URBAN SABO KATALIN,УРБАН САБО Каталин,K
申请号:
RU2011107205/04
公开号:
RU0002514824C2
申请日:
2009.07.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to compounds of general formula or , where Ar1 represents phenyl group, optionally substituted with one or several identical or non-identical halogen atoms; R1 represents hydrogen atom; R4, R5, R6a, R6b represent hydrogen atoms; Y, Z independently represent linear C1-4 alkylene group, optionally substituted with one linear C1-4 alkyl group; Ar2 stands for condensed with benzene 5-membered heterocyclic ring, containing one nitrogen atom and one sulphur atom, substituted with one linear C1-4 alkyl group, or derivative of 5- or 6-membered heterocyclic ring, containing one nitrogen atom and one sulphur atom, condensed with heteroaromatic 6-memebered ring, containing one or two nitrogen atoms, substituted with one linear C1-4 alkyl group, linear C1-4 alkoxygroup or group -NR7R8, where R7 and R8 independently stand for hydrogen atom, linear or branched C1-4 alkyl group, or R7 and R8 together with nitrogen atom form group of general formula , where R2, R3 represent linear C1-4 alkyl groups, A stands for group -CHR12, oxygen atom or group -NR9, where R12 and R9 stand for hydrogen atom or linear C1-4 alkyl group, m has value 1 or 2, n has value 1 or 2, o has value 0 or 1, p has value 0 or 1, Q stands for group -O-, group -N--H or group -N--CO-R10, where R10 stands for linear C1-4 alkyl group or -NH-R11 group, where R11 represents linear C1-4 alkyl group; and to their salts. Invention also relates to methods of obtaining therein and to based on them pharmaceutical composition, possessing antagonistic activity with respect to receptor CCR3.EFFECT: obtained are novel compounds and based on them pharmaceutical compositions, which can be applied in medicine for obtaining medication, intended for treating asthma, allergic rhinitis, atopic dermatitis, eczema, inflammatory intestinal diseases, ulcerous colitis, Crohn's disease, allergic conjunctivitis, multiple sclerosis or HIV-infection and AIDS-associated diseases.14 cl, 3 tbl, 26 ex
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