SANGKON OH,JACQUES F. BANCHEREAU,GERARD ZURAWSKI,HIDEKI UENO,LING NI
申请号：
ARP120103179
公开号：
AR088220A1
申请日:
2012.08.28
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compositions and Methods for Enhancing Th1 / Th17 cell responses and decrease Th2 cell responses.In various forms of realization of this describes the Activation of Human dendritic cells and increased T cell responses specific antigen in human dendritic cells that Express dectina - 1 and comprising an antibody specific dectina - 1 A fragment of the same, or merged with one or more antigens.It can also include LIGANDS FOR tlr2 activation to increase and improve the responses of t cells. In addition, it includes methods based on compositions that are described in the present for the treatment of allergy and Asthma.Claim 1: a composition for one or more activate antigen-presenting Cells (APC), which Express dectina - 1 to secrete IL - 23 comprising: a specific Antibody anti dectina - 1 or a fragment of it merged with one or more antigens in which the composition of them NTA cellular responses Th1 or Th2 and Th17 decreases cellular responses.Claim 2: the composition of claim 1, wherein said one or more antigens are Antigens, bacterial, fungal or viral. Claim 5: Composition of claim 1, wherein the Antigen is a subunit of HA1 of influenza a virus.Claim 15: a Pharmaceutical composition for the treatment of allergy, Asthma, or both, that includes: a specific Antibody anti dectina - 1 or a fragment of it merged with a subunit of HA1 of influenza a virus and one or more pharmaceutically acceptable excipients.Composiciones y métodos para aumentar las respuestas celulares Th1/Th17 y disminuir las respuestas celulares Th2. En diversas formas de realización de la presente se describe la activación de las células dendríticas humanas y el aumento de las respuestas de células T específicas del antígeno en células dendríticas humanas que expresan Dectina-1 y que comprenden un anticuerpo anti-Dectina-1 específico, o un fragmento del mismo fusionado con uno o más antígenos. También se pueden incluir ligandos TLR2 para mejorar la activación y para aumentar las respuestas de las células
