human transferrin anti-receptor antibody, fusion protein, DNA fragment, expression vector, mammalian cell, pharmacologically active compound and human transferrin anti-receptor antibody complex, uses of human transferrin anti-receptor antibody and fusion protein, and, methods for treating a central nervous system disorder and a central nervous system disorder accompanying pompe disease, hurler syndrome or hurler-scheie syndrome.
The present invention provides a human transferrin anti-receptor antibody or analog thereof, wherein, in the antibody heavy chain variable region, (a) cdr1 comprises the amino acid sequence shown as sequence id: 62 or sequence id: 63 , (b) cdr2 comprises the amino acid sequence shown as sequence id: 13 or sequence id: 14, and (c) cdr3 comprises the amino acid sequence sequence presented as sequence id: 15 or sequence id: 16.a presente invenção provê um anticorpo antirreceptor de transferrina humana ou um análogo do mesmo, em que, na região variável de cadeia pesada do anticorpo, (a) cdr1 compreende a sequência de aminoácidos apresentada como seq id no: 62 ou seq id no: 63, (b) cdr2 compreende a sequência de aminoácidos apresentada como seq id no: 13 ou seq id no: 14, e (c) cdr3 compreende a sequência de aminoácidos apresentada como seq id no: 15 ou seq id no: 16.
