The invention provides anti-TLR3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-TLR3 antibodies.Linvention concerne des anticorps anti-TLR3, ainsi que leurs procédés de fabrication et dutilisation. Les anticorps sont particulièrement adaptés au traitement de maladies auto-immunes ou inflammatoires à laide danticorps anti-TLR3.