Sterile pharmaceutical stable autoclaved clear aqueous compositions ofpropofol (2,6-Diisopropyl phenol) suitable for parenteral administration aredescribed. The compositions essentially consist of a complex of propofol with2-hydroxypropyl-.beta.-cyclodextrin in a weight ratio of 1:30 - 1:60. Thiscomplex of propofol with 2-hydroxypropyl-.beta.-cyclodextrin produces a clearaqueous composition that is stable to autoclaving. The composition iseffective as an anaesthetic agent. The process of making these synergisticcompositions has been described.
