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MESALAZINE TABLET HAVING IMPROVED DISSOLUTION
专利权人:
Hendrik Cornelis De Fluiter
发明人:
Hendrik Cornelis De Fluiter
申请号:
US13817805
公开号:
US20130183434A1
申请日:
2011.09.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention provides a method for preparing a mesalazine enteric coated tablet comprising: (i) granulating a composition comprising mesalazine, a pharmaceutically acceptable salt, or ester thereof, into mesalazine granulates; (ii) tabletting a core composition comprising the mesalazine granulates obtained in (i) to obtain a tablet core; (iii) coating the tablet core obtained in (ii) with at least an intermediate layer and an enteric coating; where the tablet core hardness is controlled to be comprised between 80 N and 105 N and the intermediate layer represents less than 2% by weight of the tablet.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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