GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
CUI, Haifeng,HENNESSY, Alan,JIN, Qi,MILES, Timothy James,MOSS, Stephen Frederick,PEARSON, Neil David
申请号：
PE0002362018
公开号：
PE11432018A1
申请日:
2016.08.15
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Refers to compounds of General formula (i), where Z1 or Z2 is c n is n or CH, where Z1 is n, R1, R1 is not presentR2 and R3 are independently selected from H or alkyl (C1 - C6) x1 is selected or s L1 is selected a Link - or - (C1 - C6), alkyl, - C (= o), among others X is aryl, (C5 - C14)Heteroaryl (C2 (C3 C9, C12 cycloalkyl)), among others L2 is selected a Link - or - (C1 - C6), alkyl, - C (= o),Among others, and is a heteroaryl (C1 - C5) that contains at least one heteroatom selected irrespective of o, N and s where [14C)Is optionally substituted with at least one selected Group (C1 - C6 alkyl, alkoxy, halogen C1 - C6), among others, M, N,P is an integer ranging from 0 to 8 Q is an integer ranging from 0 to 8. Or a pharmaceutically acceptable Salt thereof.It also relates to pharmaceutically acceptable salts, solvates or N - oxides comprising compounds of formula (i).Compound are preferred: 6 - ((((1R, 4R) - 4 (((6 - 3 - 5 - fluoro - metoxiquinoxalin - yl) methyl) amino) cyclohexyl) amino) methyl) - 2H - pirazino [2,3-b] [1,4] oxazin (4H) - One - 3, 6 - ((((1R, 3S,(4R) - 4 (6 - 3 - 5 - fluoro - metoxiquinoxalin - yl) methyl) amino) hidrociclohexil) amino) methyl) - 2H - pirazino [2,3-b] [1,4] oxazin - 3 (2H) - One, among others.These compounds are useful for the treatment of bacterial infections caused by Gram negative organisms such as Haemophilus influenzae, Moraxella catarrhalis, Acinetobacter baumanii,Among others, Gram positive organisms such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, among others, infections of the Upper and \/ or lower respiratory tract.Infections of skin and soft tissue and \/ or urinary tract infectionsSe refiere a compuestos de formula general (I), donde Z1 es C o N Z2 es CH o N, donde si Z1 es N, R1 no esta presente R1, R2 y R3 son seleccionados independientemente de H o alquilo (C1-C6) X1 es seleccionado de O o S L1 es seleccionado de un enlace -O-, alquilo (C1-C6), -C(=O), entre otros X es arilo (C5-C14
