VAN NIEL, MONIQUE BODIL,RAY, NICHOLAS CHARLES,ALCARAZ, LILIAN,PANCHAL, TERRY AARON,JENNINGS, ANDREW STEPHEN ROBERT,ARMANI, ELISABETTA,CRIDLAND, ANDREW PETER,HURLEY, CHRISTOPHER
申请号：
PE0009232014
公开号：
PE13702014A1
申请日:
2012.12.05
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a compound of formula (i) where W is n or o, where n is replaced with h, alkyl or cycloalkyl (C1 - C6) (c3-c5) and - OC (OC) - (OR) - NH -, among others r1 is a group of formula (IIA), (IIB), among others, where R8 and R9 are each h, alkyl (C1 - C6), among others, R10 is H, CN, entr And others R12 is H, alkyl or Halogen (C1 - C6) x1 is c, N or CH, NH R2 is a group of formula (iii),Among others, where R14 IS F, CH3, C2H5, CH2OH, among others, R15 and R16 are each CH3 and C2H5 is cicloalquileno (C5 to C7) phenyl or heteroaryl FUSED to 5 or 6 members.Preferred compounds are: 1 - 5 - [2 - (tert - butyl - 4 - 2 (IL - ethyl) - 2H - pyrazole - 3 - yl] - 3 - [(1S, 4R) - 4 - [3 - ((S) - 2 - methyl - piperidin-1-yl - [1,2,4] triazolo [4,3-a] pyridin-3 iloxi] - 6 - - - - naftalen 1,2,3,4 tetrahydro - il - 1} {1 - 5 - urea Tert Butyl 2 - [1 - (2 - dimethylamino ethyl) - 1H imidazole - 4-yl] - 2H - pyrazole - 3 - il} - 3 - [(1S, 4R) - 4 - (piperidin-1-yl) - [1,2,4] triazolo [4,3-a] pyridin - 6 - - 1,2,3, iloxi)4 - tetrahydro - naftalen - triazin-1-yl] - urea among others. It also relates to a Pharmaceutical composition. These compounds are inhibitors of the MAPK p38 Mitogen activated Kinases being useful in the treatment of AsthmaSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE W ES N U O, DONDE N ESTA SUSTITUIDO CON H, ALQUILO(C1-C6) O CICLOALQUILO(C3-C5) Y ES -OC(O)-, -OC(O)NH-, ENTRE OTROS R1 ES UN GRUPO DE FORMULA (IIa), (IIb), ENTRE OTROS, EN DONDE R8 Y R9 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS R10 ES H, CN, ENTRE OTROS R12 ES H, ALQUILO(C1-C6) O HALOGENO X1 ES C, N, CH O NH R2 ES UN GRUPO DE FORMULA (IIIa), ENTRE OTROS, EN DONDE R14 ES F, CH3, C2H5, CH2OH, ENTRE OTROS R15 Y R16 SON CADA UNO CH3 O C2H5 A ES CICLOALQUILENO(C5-C7) FUSIONADO A FENILO O HETEROARILO DE 5 O 6 MIEMBROS. SON COMPUESTOS PREFERIDOS: 1-[5-TERT-BUTIL-2-(2-MORFOLIN-4-IL-ETIL)-2H-PIRAZOL-3-IL]-3-{(1S,4R)-4-[3-((S)-2-METIL-PIPERIDIN-1-IL)-[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-6-ILOXI]-1,2,3,4-TETRAHI
