BECK, Hilary Plake,REILLY, Maureen Kay,JAEN, Juan Carlos,OSIPOV, Maksim,POWERS, Jay Patrick,SHUNATONA, Hunter Paul,WALKER, James Ross,ZIBINSKY, Mikhail,BALOG, James Aaron,WILLIAMS, David K.,MARKWALDER
申请号：
PE0008072017
公开号：
PE13292017A1
申请日:
2015.11.05
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a compound of formula I, where N and P is 0 OR 1 Z is o b is C (n, or5a), among others X is nr5a, o, C (OR), among others q n, C (CN), among others d is a Link, or, among others and it is a bicyclic heteroaryl FUSED optionally replaced, R1 and R2 are h, halogen, among others R3 and R4 are h, alkyl of C1 - C6Among others, r5a is H or c1-c6 alkyl, optionally substituted phenyl heteroaryl ring is 5 or 6 Elements, or cycloalkyl C5 - C7. Preferred compounds are: N - (4-chlorophenyl) - 2 - (trans-4 - (quinolin-1 - 4-yl) cyclohexyl) acetamide hydrochloride of N - (4-cyanophenyl) - 2 - (trans-4 - (quinolin-1 - 4-yl) cyclohexyl) acetamide, among others. It also relates to a Composition and a Pharmaceutical combination.These compounds modulate oxidoreductase Enzyme indolamina 2,3-dioxygenase, being useful in the treatment of cancerSe refiere a un compuesto de formula I, donde: n y p son 0 o 1 Z es O B es N, C(OR5a), entre otros X es NR5a, O, C(O), entre otros Q es N, C(CN), entre otros D es un enlace, O, entre otros E es un heteroarilo biciclico fusionado opcionalmente sustituido, R1 y R2 son H, halogeno, entre otros R3 y R4 son H, alquilo C1-C6, entre otros R5a es H o alquilo C1-C6 opcionalmente sustituido el anillo A es fenilo, heteroarilo de 5 o 6 elementos o cicloalquilo C5-C7. Son compuestos preferidos: N-(4-clorofenil)-2-(trans-4-(quinolin-4-il)ciclohexil)acetamida, clorhidrato de N-(4-cianofenil)-2-(trans-4-(quinolin-4-il)ciclohexil)acetamida, entre otros. Tambien se refiere a una composicion y a una combinacion farmaceutica. Dichos compuestos modulan la enzima oxidorreductasa indolamina 2,3-dioxigenasa, siendo utiles en el tratamiento del cancer
