Yufen Zhao,Ashvinikumar V. Gavai,Patrice Gill,Soong-Hoon Kim,Brian E. Fink,Libing Chen,Mark G. Saulnier,Wen-Ching Han
申请号：
US14429958
公开号：
US20150231152A1
申请日:
2013.09.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is —CH2CH2CF3 R2 is —CH2CH2CH2F, —CH2CF2CH3, —CH2CH2CF3, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, (Formulae (II), (III), (IV), (V) or (VI): R3 is H or —CH3 Ring A is phenyl or pyridinyl and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
