Wen-Ching Han,Patrice Gill,Ashvinikumar V. Gavai,Claude A. Quesnelle
申请号：
US14429945
公开号：
US20150246892A1
申请日:
2013.09.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed are compounds of Formula (I): wherein: R1 is —CH2CH2CF3 R2 is —CH2CH2CF3, or —CH2CH2CH2CF3 R3 is —CH2CF3, —CH2CN, —CH2(cyclopropyl), pyridinyl, chloropyridinyl, or tetrahydropyranyl Ring A is phenyl or pyridinyl Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
