Związki bis(fluoroalkilo)-1,4-benzodiazepinonu

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专利权人:

Bristol-Myers Squibb Company

发明人:

QUESNELLE, CLAUDE,KIM, SOONG-HOON,LEE, FRANCIS,GAVAI, ASHVINIKUMAR

申请号：

PL12711102

公开号：

PL2688873T3

申请日:

2012.03.22

申请国别(地区):

PL

年份:

2015

代理人:

摘要：

Disclosed are compounds of Formula (I) or prodrugs thereof； wherein: R1 is -CH2CF3 or -CH2CH2CF3； R2 is -CH2CF3, -CH2CH2CF3, or -CH2CH2CH2CF3； R3 is H or -CH3； each Ra is independently F, Cl, -CN, -OCH3, and/or -NHCH2CH2OCH3； and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

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