INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE NICE SOPHIA ANTIPPOLIS
发明人:
Patrick Collombat,Keith Al-Hasani,Monica Courtney,Nouha Ben-Ohtman,Elisabet Gjernes,Ahmed Mansouri
申请号：
US14431857
公开号：
US20150240235A1
申请日:
2013.09.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to an in vitro or ex vivo method for producing a population of pancreatic beta-cells, comprising the step of inhibiting the expression or the activity of Arx in a population of pancreatic alpha-cells. The present invention also relates to method for inducing the conversion of pancreatic alpha-cells in pancreatic beta-cells in a patient in need thereof.
