The action of NFB at the same time securely you control effectively, in addition obtain more effective anti- inflammation effect. Furthermore, decreasing the amount used of the steroid medicine, you obtain the equal effect. It features that the nuclear acid of MTI-II and especially arrangement number 1 or the peptide of arrangement number 2 is included. As for this MTI-II peptide, the acidic amino acid territory (arrangement number 3) it is desirable to be something which is included at least. In addition the steroid medicine of toriamushinoronasetonido and the like is jointly used in addition to the nuclear acid of MTI-II and especially arrangement number 1 or the peptide of arrangement number 2.NFκBの作用を確実に且つ効果的に抑制し、またより効果的な抗炎症効果を得る。更に、ステロイド剤の使用量を減らしても同等の効果を得る。MTI-II、特に配列番号1の核酸又は配列番号2のペプチドを含むことを特徴とする。このMTI-IIペプチドは、酸性アミノ酸領域(配列番号3)を少なくとも含むものであることが好ましい。またMTI-II、特に配列番号1の核酸又は配列番号2のペプチドに加えて、トリアムシノロンアセトニドなどのステロイド剤を併用する。