YANG, JEAN DEAN,杨政典,楊政典,CHOU, YI MAN,周怡满,周怡滿,CHEN, JUI HSIANG,陈瑞祥,陳瑞祥,LIU, HSIA WEI,刘席玮,劉席瑋,WANG, SHIAN JY,王先知,王先知,TENG, TSE MIN,邓泽民,鄧澤民,LIANG, HSIANG FA,梁祥发,梁祥發,WEI, MING CHENG,魏明正,魏明正,LU, MAGGIE J.
申请号：
TW100147907
公开号：
TWI439287B
申请日:
2011.12.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
A pH-responsive hyaluronic acid derivative is provided, including at least one of a repeat unit represented by the formula (I) , wherein HA represents a unit consisted of N-acetyl-D-glucosamine and D-glucuroninc acid q represents an interger of 2-10000 A represents a biocleavable linkage, comprising at least one of hydrazone, acetal, ketal or imine M represents at least one of a hydrophobic segment, a hydrophilic segment or an amphiphilic segment and p represents the number of [A-M] segment directly grafted on each HA unit, wherein p represents an integral of 1~4, and p is not 0 at the same time in each HA unit.本發明揭露一種酸鹼敏感的透明質酸衍生物,包括至少一個如下式(I)所示之重複單元,其中HA表示包括N-乙醯基-D-葡醣胺和D-葡醣醛酸之單元,q表示2至10000之整數;A表示一生物可斷鍵鍵結,包括腙、縮醛、縮酮或亞胺之至少一種基團;M表示一疏水分子鏈段、親水分子鏈段或親疏水兩性鏈段之至少一種,以及p表示該[A-M]直接鍵結於每一該HA單元之數量,且p為0至4之整數,且每一該HA單元之p不得同時為0。
