A method, system and computer readable medium of: providing feature data of at least one organ at risk or target volume of said patient from a database of non-transitory data stored on a data storage device of prior patients data； generating, using a data processor, a distribution of dose points of the at least one organ at risk or target volume of said patient based on said feature data； calculating, using the data processor, at least one of (i) a probability of toxicity for the at least one organ at risk or (ii) a probability of treatment failure for the at least one target volume, based on said distribution of dose points； assessing, using the data processor, a dosimetric-outcome relationship based on the calculated probability； and automatically formulating, using the data processor, a treatment plan using the dosimetric-outcome relationship to minimize the at least one treatment-related risk.
