Provided is a stable pharmaceutical composition having as an active ingredient a therapeutically effective amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof, an absorption modulator, and a diluent, wherein the absorption modulator is glycerin, and the diluent is anhydrous dibasic calcium phosphate (CaHPO4) or microcrystalline cellulose. The stable pharmaceutical composition in accordance with the present invention provides extremely low amount of R(+)-N-propargyl-1-aminoindan and could significantly reduce cost. Moreover, the anhydrous dibasic calcium phosphate (CaHPO4) used as the diluent could enhance fluidity and improve ingredients uniformity in powder molding process. The glycerin used as the absorption modulator could increase the absorption of active ingredient such as R(+)-N-propargyl-1-aminoindan.
