Yong-Chul Kim,Hyo Jin Ko,Hyun You,Jung-Hoon Yoon,Hyo-Eun Yoon
申请号：
US13563974
公开号：
US08940783B2
申请日:
2012.08.01
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a pheophorbide-α conjugate or its salt, solvate or hydrate. The pheophorbide-α conjugate of the present invention exhibiting fluorescence upon its introduction into cells and degradation inhibits the survival of various cancer cells. Especially, the conjugate of pheophorbide-α (1) and doxorubicin shows higher fluorescence intensity at lower pH (cancer environment). Therefore, the present composition for photodynamic therapy (PDT) of cancers is also very useful in detecting cancers. Interestingly, the anticancer effects of the present composition are dually exerted with help of both the photosensitizer and the anticancer drug of the present conjugates.
