MARIO MASELLIS,JOANNE KNIGHT,MAUREEN SHANNON COLLINSON,ANTHONY EDWARD LANG,JAMES LOWERY KENNEDY,JOSEPH LEVY,AMIR TCHELET,IRIS GROSSMAN,ELI EYAL,OFRA BARNETT
申请号：
ARP150101010
公开号：
AR099950A1
申请日:
2015.04.01
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Method for treating a Human subject who suffers from Parkinson's Disease (PD) with a Pharmaceutical composition comprising rasagiline, or a pharmaceutically acceptable Salt of rasagiline, and a pharmaceutically acceptable vehicle,That includes the steps of: (i) obtaining a Biological Sample which comprises a Genome of the Human subject suffering from Parkinson's disease； (ii) to evaluate the DNA or RNA of the Biological sample of the Human subject using a Probe or primer,To determine the subject of the diploid genotype single nucleotide polymorphism (SNP) rs1076560 or rs2283265； (iii) identify the Human subject as a responder predicted rasagiline is if the diploid genotype CC in rs1076560,In rs2283265 CC or cc in both rs1076560 and rs2283265； and (iv) administered Pharmaceutical composition comprising a pharmaceutically acceptable Vehicle rasagiline and the Human subject if the subject is identified as a responder to rasagiline.Claim: a set of elements [31] Diagnostic KIT to evaluate the capacity of response to treatment with rasagiline in a Human subject who suffers from Parkinson's disease, wherein the set of components comprising (i) at least one SNP specific probe rs1076 560 or rs2283265,And (ii) instructions for use of the at least one probe to assess the capacity of individual's response to treatment with rasagiline. Claim: a method to determine the identity of the alleles of less than 10.000 single nucleotide polymorphisms (SNPs) in a subject selected from the group consisting of subjects in Human Subjects diagnosed with Parkinson's disease to produce a Profile of the subject selected polymorphic, diagnosed with Parkinson's diseaseCharacterized in that it comprises (i) obtaining a Biological Sample which includes a subject selected human genome was diagnosed with Parkinson's disease； (ii) an analysis of allelic Identity by selecting at least one SNP located in rs1076560 and SNP located in rs2283265 In The genome of the selected subject who was diagnosed with
