HAN, SEON-YOUNG,SUNG, KIHO,HONG, MYUNGHYO,OH, YOUREE,HEO, JEONG-SEOK,JANG, KANG WON
申请号：
CA3091911
公开号：
CA3091911A1
申请日:
2019.05.03
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A method to treat diseases or conditions associated with the human MMP-1 gene transcription involving administration of the peptide nucleic acid derivative according to claim 1 to a subject. The present invention provides the peptide nucleic acid derivative according to claim 1 which targets 5' splice site of the human MMP-1 pre-mRNA "exon 5". The peptide nucleic acid derivatives in the present invention strongly induce splice variants of the human MMP-1 mRNA in cell and are very useful to treat conditions or diseases of skin aging associated with the human MMP-1 protein.
