SUNG, KIHO,成基浩,OH, YOUREE,吴宥利,吳宥利,HEO, JEONG-SEOK,许情奭,許情奭,JANG, KANG WON,张降愿,張降願,HAN, SEON-YOUNG,韩璿瑛,韓璿瑛,HONG, MYUNGHYO,洪铭涍,洪銘涍
申请号：
TW108111655
公开号：
TW202002991A
申请日:
2019.04.02
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
A method to treat diseases or conditions associated with the human MMP-1 gene transcription involving administration of the peptide nucleic acid derivative according to claim 1 to a subject.The present invention provides the peptide nucleic acid derivative according to claim 1 which targets 5’ splice site of the human MMP-1 pre-mRNA “exon 5”. The peptide nucleic acid derivatives in the present invention strongly induce splice variants of the human MMP-1 mRNA in cell and are very useful to treat conditions or diseases of skin aging associated with the human MMP-1 protein.一種治療與人類基質金屬蛋白酶-1(matrix metalloproteinase-1，MMP-1)基因轉錄相關的疾病或病症之方法，包含對一受試者施用如申請專利範圍第1項所述之胜肽核酸衍生物。本發明提供如申請專利範圍第1項所述之胜肽核酸衍生物，其以人類基質金屬蛋白酶-1(MMP-1)的mRNA前體「外顯子5」的5’剪接位點為目標。本發明中的胜肽核酸衍生物在細胞中強烈誘導人類基質金屬蛋白酶-1(MMP-1)的mRNA的剪接變體，且對於治療與人類基質金屬蛋白酶-1(MMP-1)蛋白相關的皮膚老化的病症或疾病非常有用。
