COWLEY PHILLIP,WISE ALAN,DAVIS SUSAN,KICZUN MICHAEL
申请号：
IN201747014703
公开号：
IN201747014703A
申请日:
2017.04.25
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
123456123456123456 12345656 313234353678910111213141516313Provided is a tryptophan 2 3 dioxygenase (TDO) and/or indoleamine 2 3 dioxygenase (IDO) inhibitor compound for use in medicine which compound comprises formula (I) wherein X and X may be the same or different and each is independently selected from C N O and S X X X and X may be the same or different and each is independently selected from C and N each bond represented by a dotted line may be present or absent provided that at least one such bond is present R R R R R and R may be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group provided that the number of R R R R R and Rgroups present is such that the respective valencies of X X X X X and X are maintained and wherein at least one of R and Rcomprises a group Y wherein Y is a group having a formula selected from (II) (III) (IV) (V) (VI) (VII) wherein L may be present or absent and may be a substituted or unsubstituted organic linking group R and R may be the same or different and are selected from H and a substituted or unsubstituted organic group each R may be the same or different and is selected from H and a substituted or unsubstituted organic group R is selected from a substituted or unsubstituted alcohol group or ether group each R may be the same or different and is selected from H and a substituted or unsubstituted organic group X may be selected from C and N X X X X X X X X and X may be the same or different and each is independently selected from C N O and S each bond represented by a dotted line may be present or absent and each R may be the same or different and is selected from H and a substituted or unsubstituted organic group.
