A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil and at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically and a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry and optionally krill oil or rosehips and resveratrol and at least one of Aframomum melegueta and astaxanthin. Based ON the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and/or inflammatory response, and subsequently treat diseases and/or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis and osteoporosis and Alzheimers disease.
